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KMID : 0387820170240020148
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Clinical Pediatric Hematology-Oncology
2017 Volume.24 No. 2 p.148 ~ p.152
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A Case of Pediatric Precursor B-cell Acute Lymphoblastic Leukemia Associated with Translocations (14;18)(q32;q21) and (8;9)(q24;p13)
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Kim Hye-Ji
Kim Hye-Ry
Koh Kyung-Nam
Im Ho-Joon
Seo Jong-Jin
Seo Eul-Ju
Park Chan-Jeoung
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Abstract
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Precursor B-cell acute lymphoblastic leukemia (ALL), which is the most common subtype of pediatric acute leukemia, generally has a good prognosis. However, the prognosis also depends on the genetic abnormalities of the leukemic blast. Concurrent MYC and IGH/BCL2 translocations have recently been reported as a “double hit” in adult patients, but non-immunoglobulin (non-IG)/MYC translocation has rarely been reported. In this paper, we report a case of pediatric precursor B-cell ALL associated with translocations (14;18)(q32;q21) and (8;9)(q24;p13). The patient was a previously healthy 13-year-old boy. Complete remission was not achieved after first-line four-drug induction chemotherapy; thus, intensive salvage regimen, including high-dose cytarabine and L-asparaginase, were administered, which resulted in morphologic remission. However, his dis-ease relapsed during the second cycle of salvage regimen, and he died of sepsis-induced multiorgan failure.
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KEYWORD
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Pediatric, Precursor B-cell lymphoblastic leukemia, Translocations, MYC, BCL2
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